If a dose is forgotten, this should not be corrected by increasing the next dose. It is recommended that this dose be taken shortly before or during a substantial breakfast or - if none is taken - shortly before or during the first main meal. Normally a single daily dose of Glims is sufficient. The combination therapy should be initiated under close medical supervision. While maintaining the Glims dose, insulin treatment is started at a low dose and titrated up depending on the desired level of metabolic control. In patients not adequately controlled with the maximum daily dose of Glims, concomitant insulin therapy can be initiated if necessary. While maintaining the metformin dose, the Glims therapy is started with a low dose, and is then titrated up depending on the desired level of metabolic control up to the maximum daily dose. In patients not adequately controlled with the maximum daily dose of metformin, concomitant Glims therapy can be initiated. The maximum recommended dose is 6 mg Glims per day. If control is unsatisfactory, the dosage should be increased, based on the glycaemic control, in a stepwise manner with an interval of about 1 to 2 weeks between each step, to 2, 3, or 4 mg Glims per day.Ī dosage of more than 4 mg Glims per day gives better results only in exceptional cases. If good control is achieved, this dosage should be used for maintenance therapy.įor the different dosage regimens appropriate strengths are available. The dosage is determined by the results of blood and urinary glucose determinations. Tablets or insulin cannot compensate if the patient does not keep to the recommended diet. The basis for successful treatment of diabetes is a good diet, regular physical activity, as well as routine checks of blood and urine.
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